Omentin is a recently recognised gene highly localised to the omental tissue (visceral adipose tissue). Neural fat cell circuitry. Symposium; Program and abstracts of the 63rd scientific sessions of the American Diabetes Association. 2003; New Orleans Omentin is present in the stromal vascular cells in the adipose tissue rather than in the adipocytes. Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1253-61 Omentin is predominantly expressed in the visceral adipose tissue than the subcutaneous tissue, with the omentin mRNA being 150 times higher in the visceral adipose tissue. Omentin has also been detected in human blood using western blot analysis, and seems to increase insulin-stimulated glucose uptake in 3T3-L1 adipocytes in mice. Omentin seems to increase Akt phosphorylation irrespective of insulin presence. Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1253-61 Its role in glucose metabolism and obesity remains to be described; an insulin-sensitising action is possible. Expert Opin Pharmacother. 2005 Jun;6(6):863-72. Differences in Omentin expression has been noted in adipose tissue from normals and patients with inflammatory bowel disease although its significance is unknown. Biochim Biophys Acta. 2005 Dec 30;1732(1-3):96-102.